Think I founf the issue (searching on here, not Google) Few
links ..
http://www.telerik.com/forums/unable-to-cast-object-of-type-telerik-web-ui-radgrid-to-type-telerik-web-ui-gridtableview
leads to
http://www.telerik.com/forums/255649-unable-to-cast-object-of-type-telerik-web-ui-radgrid-to-type-telerik-web-ui-gridtableview
and then
http://weblogs.asp.net/scottgu/gotcha-don-t-use-xhtmlconformance-mode-legacy-with-asp-net-ajax
Which we have, need to remove this in the Web.Config :-
<xhtmlConformance mode="Legacy"/>
http://www.telerik.com/forums/unable-to-cast-object-of-type-telerik-web-ui-radgrid-to-type-telerik-web-ui-gridtableview
leads to
http://www.telerik.com/forums/255649-unable-to-cast-object-of-type-telerik-web-ui-radgrid-to-type-telerik-web-ui-gridtableview
and then
http://weblogs.asp.net/scottgu/gotcha-don-t-use-xhtmlconformance-mode-legacy-with-asp-net-ajax
Which we have, need to remove this in the Web.Config :-
<xhtmlConformance mode="Legacy"/>